Endocrine Abstracts

Objective: To measure the levels of 25-hydroxyvitamin D (25(OH)D) and vitamin D binding protein (VDBP) and assess their relationships with metabolic features in patients with the polycystic ovary syndrome (PCOS).Methods: 267 women, aged 20–35 years (24.7±4.9): 167 with PCOS, 100 healthy women as a control group were studied. Study groups were divided according to body mass index (BMI). Biochemical and hormonal parameters, 25(OH)D, VDBP were mea...

Background: The Phase III PAOLA study assessed the efficacy and safety of pasireotide LAR versus continued treatment with octreotide LAR or lanreotide Autogel in patients with uncontrolled acromegaly. The current analysis investigated overall baseline characteristics and response rates to pasireotide according to co-morbidities.Methods: Patients were classified into five groups of co-morbidities related to acromegaly: glucose- (n=104), endocrine...

Results of metabolomic studies showed the relation of branched-chain amino acids (BCAA) and aromatic amino acids (AAA) with metabolic disorders.Basing on this observation we assessed amino acid profile in 286 professionally active men (aged 36–60 years). 141 of them met the criteria of metabolic syndrome (MS) and remaining 142 served as controls.Quantitative analysis of BCAA (leucine-LEU, valine-VAL, isoleucine- ILE) and AAA (...

Introduction: Acromegaly is a rare diseaseresulting most commonly from pituitary adenoma. A chronic increase of growth hormone (GH) and insulin-like factor 1 (IGF-1) leads to many systemic complications including osteoporosis and fractures. Radiofrequency echographic multi-spectrometry (REMS) is a new non-ionizing technique to diagnose osteoporosis.Purpose: The objective of the study was to evaluate bone mineral density (BMD) by REMS in patient...

Background: Patients with acromegaly have substantially reduced quality of life (QoL). Delayed diagnosis is common and a long duration of untreated acromegaly leads to decreased QoL and increased morbidity and mortality.Aim: This longitudinal study examined QoL in patients with acromegaly who received lanreotide autogel.Material and Methods: This was a 2-year prospective, observational, multicenter study conducted in Poland (NCT023...

Introduction: ‘Forgotten goiter’ is defined as a mediastinal thyroid mass discovered after total thyroidectomy. It is a rare clinical finding, usually asymptomatic.Case report: 88-years old woman was admitted to the Endocrinology Department with a suspicion of the retrosternal goiter. In her medical history there was thyroidectomy performed 16 years before because of multinodular goiter and she had recurrent lower respiratory tract infections...

Aim: The aim of multi-center, observational study was to assess the outcome of the treatment with somatostatin analogue octreotide-LAR (O-LAR) patients with acromegaly.Material: Material consisted of 360 patients (60% women) aged 18–84 years (mean 45.5; S.D.±12.9) with active acromegaly. Prior to the inclusion 172 patients underwent unsuccessful neurosurgery.Methods: Observation was planned for 1 year. O-LA...

Background: Acromegaly is a rare disease, mostly caused by a GH (growth hormone)-secreting pituitary adenoma. The pathomechanism of bone complications remains not fully explored. The fibroblast growth factor-23 (FGF-23)/Klotho axis regulates phosphate and vitamin D metabolism.Objectives: The study aimed primarily at evaluating FGF-23 and Klotho concentrations with regard to acromegaly activity. The secondary goal was to identify associations between FGF-...

69-year old male was diagnosed with non-secreting pituitary macroadenoma (25x 15x 15mm) in 2008. Patient underwent two transsphenoidal surgeries and stereotactic radiotherapy in 2008 and 2009. Tumor recurrence was noticed on MRI in 2016. In 2017 urgent right pterional craniotomy was performer due to right eyelid dropping with ocular nerves palsy. Despite surgery further growth of the tumor (32x 22x 31mm) was reported in 2018, followed by increased ACTH level and hypercortisole...

Background: Polycystic ovary syndrome (PCOS) is a condition affecting up to 20% of reproductive-aged women. PCOS is associated with obesity and serious metabolic complications. There is a lack of research evaluating differences in metabolic complications between hyperandrogenic physically active and inactive individuals.Objective: We used a cross-sectional study to compare the risk of obesity, metabolic syndrome, visceral adipose index, and insulin resis...